Anti-Aging Technology
Aging of human skin occurs via two independent yet related mechanisms: intrinsic (natural) aging or extrinsic (photoaging). Intrinsic aging progresses as a consequence of growing older and altered cell function results in skin deficiencies such as fine lines, skin thinning, decreased quality of wound repair, and an increased susceptibility to wounds that fail to heal. Extrinsic photoaging occurs following prolonged exposure to solar ultraviolet (UVR) radiation and is characterized by skin thickening, rough texture, coarse wrinkles, and age spots.
Following UVR light exposure, a chain reaction of biochemical events is triggered that overrides the normal functioning of skin cells and sends them into a survival or death mode. A state of inflammation is established and immune cells are activated resulting in the release of chemical entities to defend against foreign bodies and to activate protective mechanisms. These processes result in the production of molecules that cause cell death, induce skin pigment synthesis to shield the skin against future UVR insults, and induce enzymes called metalloproteinases that break down the skin matrix, thereby causing the skin to sag and wrinkle. Furthermore, the normal production of collagen is inhibited while elastin is stimulated, resulting in solar elastosis. It is now widely accepted that exposed skin in most individuals remains in a constant state of low level UVR-induced inflammation, and that this chronic low level inflammation is responsible for the signs of skin aging that appear in middle age. A typical photoaging response is illustrated as follows Photoaging.
Intrinsic aging produces many of the same changes in the skin as photoaging, but they take longer to appear. Naturally aged skin cells exhibit a gene expression pattern that resembles an inflammatory response in that they stop producing collagen and turn on the enzymes that break down the skin matrix. Additionally, inflammatory mediators are released and this inappropriately recruits inflammatory cells into tissue. A typical intrinsic aging response is illustrated as follows Intrinsic Aging.
The discovery of a Revolutionary Anti-Aging Molecule
Clearly there is a need for a topical therapeutic to halt or even reverse the process of aging. Therametics scientists have determinedthe matrix forming and degrading proteins that are crucial for the stopping or reversal of the aging process. Based on this knowledge, Therametics scientists have developed a proprietary cell and molecular biology based screening strategy (Therascreen) which has identified several novel compounds that increase the production of matrix forming collagen and decrease the production of matrix degrading metalloproteinases. A diagram of the anti-aging screening strategy is illustrated as follows Anti-aging Therascreen. Using this screening strategy, Therametics scientists have determined that the patented Therosol®IV Complex reduces sun-induced tissue destruction by blocking the production of matrix degrading enzymes. In addition, Therosol®IV Complex increases the production of collagen and elastin, as well as reduce the expression of MMP enzymes. These two effects slow the aging process and can even aid in rebuilding the dermal matrix, which reduces the appearance of new and existing wrinkles and fine lines. Thus, treatment of aged skin with Therosol®IV Complex has significant effects in restoring skin integrity, reducing wrinkles, and improving the overall appearance of the skin. Therosol®IV Complex is the active ingredient in the anti-aging line. To learn more about or order the Therametics line of products, Click Here.